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Pioneering Research

Samuel Gross, M.D., the foremost surgeon of his day, served as chairman of the Department of Surgery at the University of Louisville from 1841-1856. He is best known for establishing the famous Gross Clinic, whereas few may know that he also established an active and innovative surgical research laboratory-a rarity at that time. Our current research efforts are reflected in this rich history and by our forward-thinking investigators with pioneering research activities. We are proud to be nationally recognized for cutting-edge advances through research in cancer treatment and early detection; organ transplantation; cardiovascular biomechanics and transplantation; hand biomechanics and transplantation; alternatives to immunosuppressive therapy; tissue ischemia; pediatric surgery research; plastic and reconstructive surgery; prevention of surgical infections; as well as treatment of digestive diseases, pneumonia, and shock.

Several of our faculty investigators have received awards from the National Institutes of Health (NIH). You will find a description of our NIH-funded research projects on our website at the link NIH Funding. As our leader, the Sam and Lolita Weakley Professor and Chair of the Department of Surgery, Kelly M. McMasters, M.D., Ph.D., is principal investigator of his own NIH R01 research grant award mechanism for his work with E2F-1 cancer gene therapy. Dr. McMasters is also author and principal investigator of one of the largest studies on melanoma (AboutMelanoma.com) and initiated the University of Louisville Breast Cancer Sentinel Lymph Node Study (AboutBreastHealth.com). Within the Division of General Surgery, Drs. William G. Cheadle and R. Neal Garrison both have had continuous VA Merit Review funding for over 15 years. Other grants or patents may be found at the following links: trials, patents, and other grant funding